REVERSIBLE LEUKOENCEPHALOPATHY RELATED WI TH HIGH-DOSE CYCLOSPORINE-A

We report a case of leucoencephalopathy with tremor and generalized mo tor seizures a few days after introduction of cyclosporin A (Cy A) in a kidney recipient There was a relationship between acute neurological symptoms and high and sudden blood level of Cy A (1 260 ng/ml; therap eutic range: 120-275 ng/ml). White-matter hypodensities at CT scanning and severe slow-waves abnormalities at EEG were present All neurologi cal symptoms were reversible after Cy A level was lowered Three months later, a blood Cy A level at 21 7 ng/ml due to nicardipine co-adminis tration resulted in severe tremor and was reversed by decreasing blood Cy A level to 126 ng/ml.