S-ADENOSYLMETHIONINE IN RAT-LIVER CIRRHOSIS

Authors
CUTRIN C MENINO MJ CARBALLO C PARAFITA MA PEREZBECERRA E BARRIO E
Citation
C. Cutrin et al., S-ADENOSYLMETHIONINE IN RAT-LIVER CIRRHOSIS, Research communications in substance abuse, 14(2-3), 1993, pp. 159-167
Citations number
21
Categorie Soggetti
Substance Abuse
Journal title
Research communications in substance abuse → ACNP
ISSN journal
01930818
Volume
14
Issue
2-3
Year of publication
1993
Pages
159 - 167
Database
ISI
SICI code
0193-0818(1993)14:2-3<159:SIRC>2.0.ZU;2-M
Abstract
An experimental model of cirrhosis in rats, by means carbon tetrachlor ide (CCl4) and ethanol during two months, was used to assess the effec tiveness of S-adenosylmethionine. Histological studies of the liver an d examination of different biochemical parameters of hepatic function were also employed. Bilirubin and lactic acid levels decreased signifi cantly in the group treated with S-adenosylmethionine in comparison wi th the CCl4 + ethanol group. Histologic liver studies showed a signifi cant improvement relative to fatty liver, Mallory bodies, infiltrate p olymorphonuclear and perivenular fibrosis. A slight decrease in cirrho sis was observed in the animals treated with S-adenosylmethionine.