PLEUROTUS FUNGI PRODUCE MEVINOLIN, AN INHIBITOR OF HMG COA REDUCTASE

Authors
GUNDECIMERMAN N PLEMENITAS A CIMERMAN A
Citation
N. Gundecimerman et al., PLEUROTUS FUNGI PRODUCE MEVINOLIN, AN INHIBITOR OF HMG COA REDUCTASE, FEMS microbiology letters, 113(3), 1993, pp. 333-337
Citations number
19
Categorie Soggetti
Microbiology
Journal title
FEMS microbiology letters → ACNP
ISSN journal
03781097
Volume
113
Issue
3
Year of publication
1993
Pages
333 - 337
Database
ISI
SICI code
0378-1097(1993)113:3<333:PFPMAI>2.0.ZU;2-8
Abstract
Fungi of the genus Pleurotus were shown to produce the 3-hydroxy-3-met hylglutaryl-CoA reductase inhibitor mevinolin. Crude methanol extracts and the purified inhibitor from three different species, P. sapidus, P. saca and P. ostreatus, were tested using the solubilized microsomal HMGCoA reductase from Chinese hamster ovary cells. The identity of th e inhibitor was also confirmed by thin layer chromatography, high pres sure liquid chromatography and mass spectroscopy.