EFFECTS OF A NOVEL MELATONIN ANALOG ON CIRCADIAN-RHYTHMS OF BODY-TEMPERATURE AND ACTIVITY IN YOUNG, MIDDLE-AGED, AND OLD RATS

Authors
KOSTERVANHOFFEN GC MIRMIRAN M BOS NPA WITTING W DELAGRANGE P GUARDIOLALEMAITRE B
Citation
Gc. Kostervanhoffen et al., EFFECTS OF A NOVEL MELATONIN ANALOG ON CIRCADIAN-RHYTHMS OF BODY-TEMPERATURE AND ACTIVITY IN YOUNG, MIDDLE-AGED, AND OLD RATS, Neurobiology of aging, 14(6), 1993, pp. 565-569
Citations number
55
Categorie Soggetti
Neurosciences
Journal title
Neurobiology of aging → ACNP
ISSN journal
01974580
Volume
14
Issue
6
Year of publication
1993
Pages
565 - 569
Database
ISI
SICI code
0197-4580(1993)14:6<565:EOANMA>2.0.ZU;2-K
Abstract
Circadian rhythms of body temperature and activity were recorded in yo ung, middle-aged, and old rats. A new melatonin analog, S20242, was ad ministered daily around the onset of darkness for a 2-week period. Com pared to the young animals, there was a significant age-related reduct ion in the amplitude and stability of body temperature and activity in both the middle-aged and old rats. In these two groups there was an i mprovement of the circadian rhythm of body temperature as a result of daily application of the melatonin analog.