THE HIGH-INCIDENCE OF ATRIAL THROMBOSIS IN MICE GIVEN DOXORUBICIN

Doxorubicin (DX)-treated mice represent an animal model for studying n ew drugs for heart disease. Coincidentally, in the collection of damag ed myocardial tissue, thrombosis was detected in the atrium. The incid ence reached 75% in mice given 4 mg/kg DX iv 10 times. They were white thrombi consisting of the fibrin, platelets, and neutrophils. Cardiac muscle damage was more prominent in the atria than in the ventricles. Light microscopically, vacuolization and degeneration of atrial myocy tes and interstitial inflammatory cell infiltration were observed. Ele ctron microscopy revealed dilatation of the sarcoplasmic reticulum and an increase in number of normal and/or degenerate mitochondria. Infla mmation extended from the cardiac muscle to the endocardium. The cause of atrial thrombosis in DX-treated mice is unknown but may relate to endocardial damage and changes of blood flow in the atrium secondary t o cardiac muscle damage. DX-treated mice could serve as an experimenta l animal model for the evaluation of efficacy and toxicity of antithro mbotic or antiplatelet drugs.