The objective of the studies reported in this paper was to determine t
he incidence as well as the final diagnostic outcome of rectal bleedin
g presenting in general practice. Because of the wide variety observed
in incidence rates among 83 general practitioners (GPs) in the first
study (A) an additional study (B) was undertaken. In study B with 10 G
Ps special efforts were made to maximize the catchment rate. The mean
'consultation incidence rate' was 7 per 1000 people per year. A follow
-up period of at least 1 year was applied to establish the final diagn
ostic conclusion. Occurrence of colorectal cancer was found in 3% of p
atients with rectal bleeding. This may represent an overestimation of
the prior probability since there was a selection in favour of patient
s with clinically relevant rectal bleeding. In about 90% of patients r
ectal bleeding was related to minor ailments or self-limiting disorder
s. Further study on predictive values of (combinations of) other signs
and symptoms is necessary to develop clinical recommendations.