Wearing a special thermometric brassiere, twenty-five normal women sel
f-measured their breast surface temperature. The subjects averaged 39
years of age and all were parous. Observations were made for one hour
each evening for one menstrual cycle under semi-standardized domestic
conditions. They also collected daily samples of saliva for radioimmun
oassay of progesterone concentration. The surface temperature of the b
reast is relatively cold around mid-cycle; thereafter, and without int
erruption in averaged data, the temperature increases steadily by abou
t 1 degrees C over the 12 days of the luteal phase; around the time of
the menses, it falls rapidly. This heat rhythm does not occur in peri
-menopausal low progesterone menstrual cycles or in patients where the
breast tissue has been irradiated for cancer treatment.