THE EFFECTS OF INTERMITTENT PROGESTERONE UPON TAMOXIFEN INHIBITION OFTUMOR-GROWTH IN THE 7,2-DIMETHYLBENZANTHRACENE RAT MAMMARY-TUMOR MODEL

Authors
GIBSON DFC JOHNSON DA LANGANFAHEY SM LABABIDI MK WOLBERG WH JORDAN VC
Citation
Dfc. Gibson et al., THE EFFECTS OF INTERMITTENT PROGESTERONE UPON TAMOXIFEN INHIBITION OFTUMOR-GROWTH IN THE 7,2-DIMETHYLBENZANTHRACENE RAT MAMMARY-TUMOR MODEL, Breast cancer research and treatment, 27(3), 1993, pp. 283-287
Citations number
26
Categorie Soggetti
Oncology
Journal title
Breast cancer research and treatment → ACNP
ISSN journal
01676806
Volume
27
Issue
3
Year of publication
1993
Pages
283 - 287
Database
ISI
SICI code
0167-6806(1993)27:3<283:TEOIPU>2.0.ZU;2-I
Abstract
The development of endometrial cancer is a potential risk during long- term tamoxifen therapy for breast cancer. In order to protect the uter us, progestin treatment has been proposed for these patients. However, within the 7,12-dimethylbenzanthracene-induced rat mammary model, pro gesterone is known to reverse the antitumor effects of tamoxifen. This study shows that progesterone administered intermittently still rever ses the antitumor effects of tamoxifen in this model. This effect of p rogesterone is not due to a decrease in the tissue levels of tamoxifen , and may be direct, via the progesterone receptor.