NEW INDOLE-DERIVATIVES AS POTENT AND SELECTIVE SEROTONIN UPTAKE INHIBITORS

Authors
MIGNANI S DAMOUR D DOBLE A LABAUDINIERE R MALLERON JL PIOT O GUEREMY C
Citation
S. Mignani et al., NEW INDOLE-DERIVATIVES AS POTENT AND SELECTIVE SEROTONIN UPTAKE INHIBITORS, Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 1913-1918
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
10
Year of publication
1993
Pages
1913 - 1918
Database
ISI
SICI code
0960-894X(1993)3:10<1913:NIAPAS>2.0.ZU;2-O
Abstract
A new series of serotonin uptake inhibitors is described. Compounds 2c ,f,g,o and r exhibit potent and selective activities in a binding assa y for the 5-HT uptake site. Compounds 2c, 2f and 2g behave like strong in vivo serotonin uptake inhibitors.