SYNTHESIS AND CYTOTOXIC ACTIVITY OF (+ -) OCTADECYLPHOSPHODITHIONYL-1-MYO-INOSITOL/

Authors
ALISI MA BRUFANI M FILOCAMO L GOSTOLI G CELLAI L IANNELLI MA MELINO G CESTA MC LAPPA S
Citation
Ma. Alisi et al., SYNTHESIS AND CYTOTOXIC ACTIVITY OF (+ -) OCTADECYLPHOSPHODITHIONYL-1-MYO-INOSITOL/, Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 1931-1934
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
10
Year of publication
1993
Pages
1931 - 1934
Database
ISI
SICI code
0960-894X(1993)3:10<1931:SACAO(>2.0.ZU;2-7
Abstract
The synthesis of the phosphatidylinositol (PI) analogue (+/-)-octadecy lphosphodithionyl-1-myo-inositol is described. The cytotoxic activity on K562 erythroleukaemic cells and the effect on the activity of PI sp ecific phospholipase C (PI-PLC) from human platelets are reported.