Sj. Teague et Mj. Stocks, THE AFFINITY OF THE EXCISED BINDING DOMAIN OF FK-506 FOR THE IMMUNOPHILIN FKBP12, Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 1947-1950
The affinity of the binding domain of FK-506 was determined, in the ab
sence of the constraints imposed upon it by the macrocyclic framework.
Removal of those parts of FK-506 not involved in the binding of FK-50
6 to FKBP12 results in a 50-fold drop in affinity.