NOVEL POLYAMIDE INDUCERS OF HL-60 CELLULAR-DIFFERENTIATION

Authors
DUBOWCHIK GM CORNELL LA CROSSWELL AR FIRESTONE RA
Citation
Gm. Dubowchik et al., NOVEL POLYAMIDE INDUCERS OF HL-60 CELLULAR-DIFFERENTIATION, Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 1965-1970
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
10
Year of publication
1993
Pages
1965 - 1970
Database
ISI
SICI code
0960-894X(1993)3:10<1965:NPIOHC>2.0.ZU;2-M
Abstract
Four polyamides based on the structure of spermine and spermidine were prepared and tested in vitro in an HL-60 cell differentiation assay. Their activity was compared with that of hexamethylene bisacetamide (H MBA) 1 whose optimal activity (ca. 65% differentiation) is at its IC50 of 4 mM. Triamides 7 and 13 were as good as or superior to 1 at conce ntrations (16 mM) which were below their IC(50)s.