SYNTHESIS OF NON REDUCIBLE INHIBITORS FOR TRYPANOTHIONE REDUCTASE FROM TRYPANOSOMA-CRUZI

Authors
TROMELIN A MOUTIEZ M MEZIANECHERIF D AUMERCIER M TARTAR A SERGHERAERT C
Citation
A. Tromelin et al., SYNTHESIS OF NON REDUCIBLE INHIBITORS FOR TRYPANOTHIONE REDUCTASE FROM TRYPANOSOMA-CRUZI, Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 1971-1976
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
10
Year of publication
1993
Pages
1971 - 1976
Database
ISI
SICI code
0960-894X(1993)3:10<1971:SONRIF>2.0.ZU;2-Y
Abstract
A good alternative substrate for the trypanothione reductase from Tryp anosoma cruzi N,N'-bis(benzyloxycarbonyl)-L-cysteinylglycine 3-dimethy laminopropylamide disulfide, has been modified at the disulfide bridge to obtain non reducible derivatives. Cystine was replaced by three na tural diamino diacids (djenkolic acid, lanthionine and cystathionine). The compounds were selective linear competitive inhibitors for trypan othione reductase versus trypanothione, its physiological substrate.