SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF HYDROXYACETOPHENONE-SUBSTITUTED BENZOPHENONE XANTHONE LEUKOTRIENE B-4 RECEPTOR ANTAGONISTS/

Authors
SAWYER JS BALDWIN RF FROELICH LL SAUSSY DL JACKSON WT
Citation
Js. Sawyer et al., SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF HYDROXYACETOPHENONE-SUBSTITUTED BENZOPHENONE XANTHONE LEUKOTRIENE B-4 RECEPTOR ANTAGONISTS/, Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 1981-1984
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
10
Year of publication
1993
Pages
1981 - 1984
Database
ISI
SICI code
0960-894X(1993)3:10<1981:SAPAOH>2.0.ZU;2-#
Abstract
The preparation and pharmacologic activity of two new hybrid LTB(4) re ceptor antagonists, 1 and 2 (LY282210), are reported. These compounds are among the most potent in vitro LTB(4) receptor antagonists yet des cribed, and add new insight into the critical pharmacophores of the LT B(4) receptor.