DIESTERS OF ZARAGOZIC ACID-A - SYNTHESIS AND BIOLOGICAL-ACTIVITY

Authors
CHIANG YCP BIFTU T DOSS GA PLEVYAK SP MARQUIS RW BERGSTROM JD KURTZ MM REW DJ BERGER GD
Citation
Ycp. Chiang et al., DIESTERS OF ZARAGOZIC ACID-A - SYNTHESIS AND BIOLOGICAL-ACTIVITY, Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 2029-2034
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
10
Year of publication
1993
Pages
2029 - 2034
Database
ISI
SICI code
0960-894X(1993)3:10<2029:DOZA-S>2.0.ZU;2-7
Abstract
Diesters of zaragozic acid A were synthesized and tested in rat liver squalene synthase and oral mouse cholesterol biosynthesis assays. Of t hese, 3-isopentyl-4-pivaloyloxymethyl and 3-isopentyl-4-acetoxymethyl esters gave ED(50)'s of 9 mg/kg and 6 mg/kg, respectively, in the oral mouse assay.