NEUROTENSIN RECEPTOR-BINDING AND ANTINOCICEPTIVE ACTIVITY FOR LIPOPHILIC N-ALPHA-AMIDO NEUROTENSIN(9-13) ANALOGS

Authors
CAIN GA CHRISTOS TE JOHNSON AL POTTORF RS CONFALONE PN TAM SW SCHMIDT WK
Citation
Ga. Cain et al., NEUROTENSIN RECEPTOR-BINDING AND ANTINOCICEPTIVE ACTIVITY FOR LIPOPHILIC N-ALPHA-AMIDO NEUROTENSIN(9-13) ANALOGS, Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 2055-2060
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
10
Year of publication
1993
Pages
2055 - 2060
Database
ISI
SICI code
0960-894X(1993)3:10<2055:NRAAAF>2.0.ZU;2-#
Abstract
A series of lipophilic Na-amido-neurotensin(9-13) analogs was prepared . These acylated pentapeptides exhibited good neurotensin receptor bin ding, as well as in vivo analgesic activity via i.c.v. and even intrav enous routes of administration.