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ITA
ENG
JUSTICIDIN-E - A NEW LEUKOTRIENE BIOSYNTHESIS INHIBITOR
Authors
THERIEN M
FITZSIMMONS BJ
SCHEIGETZ J
MACDONALD D
CHOO LY
GUAY J
FALGUEYRET JP
RIENDEAU D
Citation
M. Therien et al., JUSTICIDIN-E - A NEW LEUKOTRIENE BIOSYNTHESIS INHIBITOR, Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 2063-2066
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters
→
ACNP
ISSN journal
0960894X
Volume
3
Issue
10
Year of publication
1993
Pages
2063 - 2066
Database
ISI
SICI code
0960-894X(1993)3:10<2063:J-ANLB>2.0.ZU;2-B
Abstract
Justicidin E, an arylnaphthalene lignan, has been identified as a pote nt inhibitor of leukotriene biosynthesis by human leukocytes (IC50 = 7 0 nM) and a non-redox inhibitor of 5-lipoxygenase activity.