SYNTHESIS OF A CATECHOL METABOLITE OF DILEVALOL

Authors
TULSHIAN DB BERCOVICI A
Citation
Db. Tulshian et A. Bercovici, SYNTHESIS OF A CATECHOL METABOLITE OF DILEVALOL, Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 2073-2076
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
10
Year of publication
1993
Pages
2073 - 2076
Database
ISI
SICI code
0960-894X(1993)3:10<2073:SOACMO>2.0.ZU;2-S
Abstract
A biotransformation study of dilevalol in various species identified n ine metabolites which included a family of catechols. The site of arom atic hydroxylation to produce the catechol metabolite 2 was unequivoca lly established by total synthesis. Comparison of the spectral data sh owed that the synthetic and isolated material were identical.