SELECTIVE INACTIVATION OF MONOAMINE-OXIDASE-B BY AMINOETHYL 3-CHLOROBENZYL ETHER

Authors
DING CZ SILVERMAN RB
Citation
Cz. Ding et Rb. Silverman, SELECTIVE INACTIVATION OF MONOAMINE-OXIDASE-B BY AMINOETHYL 3-CHLOROBENZYL ETHER, Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 2077-2078
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
10
Year of publication
1993
Pages
2077 - 2078
Database
ISI
SICI code
0960-894X(1993)3:10<2077:SIOMBA>2.0.ZU;2-E
Abstract
Aminoethyl 3-chlorobenzyl ether (3), synthesized by the reaction of 3- chlorobenzyl bromide with aminoethanol and NaH, was shown to be a time -dependent reversible inactivator of both monoamine oxidase A and B. T he selectivity for inactivation of monoamine oxidase B, as measured by (k(inact)/K-I)(B)l(k(inact)/K-I)(A), is 1700.