SYNTHESIS AND TESTING OF SUBSTITUTED PHENYLTHIORIBOSE ANALOGS AGAINSTKLEBSIELLA-PNEUMONIAE

Authors
WINTER RW CORNELL KA JOHNSON LL RISCOE MK
Citation
Rw. Winter et al., SYNTHESIS AND TESTING OF SUBSTITUTED PHENYLTHIORIBOSE ANALOGS AGAINSTKLEBSIELLA-PNEUMONIAE, Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 2079-2082
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
10
Year of publication
1993
Pages
2079 - 2082
Database
ISI
SICI code
0960-894X(1993)3:10<2079:SATOSP>2.0.ZU;2-0
Abstract
Halogen substituted analogs of 5-(phenylthio)ribose were synthesized a nd tested as inhibitors of the methylthioribose kinase-containing path ogen, Klebsiella pneumoniae. All of the compounds exhibit good activit y against the organism. 5-(4-Iodophenylthio)ribose demonstrated the mo st potent inhibitory effects with a 50% inhibitory concentration (IC50 ) value of similar to 2.5 picomolar (0.0009 ng/ml).