SYNTHESIS OF (2R,3R)-, (2S,3S)-, (2R,3S)- AND (2S,3R)-IMIDAZOLE GLYCEROL PHOSPHATES (IGP) - SUBSTRATES FOR IGP-DEHYDRATASE (IGPD)

Authors
SAIKA H FRUH T IWASAKI G KOIZUMI S MORI I HAYAKAWA K
Citation
H. Saika et al., SYNTHESIS OF (2R,3R)-, (2S,3S)-, (2R,3S)- AND (2S,3R)-IMIDAZOLE GLYCEROL PHOSPHATES (IGP) - SUBSTRATES FOR IGP-DEHYDRATASE (IGPD), Bioorganic & medicinal chemistry letters, 3(10), 1993, pp. 2129-2134
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
10
Year of publication
1993
Pages
2129 - 2134
Database
ISI
SICI code
0960-894X(1993)3:10<2129:SO(((A>2.0.ZU;2-3
Abstract
D-erythro-(2R,3S)-Imidazole glycerol phosphate (IGP) and its stereoiso mers [(2S,3R), (2R,3R), (2S,3S)] have been synthesized via the Evans a ldol reaction. The stereochemical assignments of these isomers and the ir IGPD-substrate activities were studied.