LOW-GRADE LYMPHOMA FOLLOWING INTENSIVE TREATMENT OF LARGE-CELL LYMPHOMA

Progression of a low-grade non-Hodgkin's lymphoma into a more aggressi ve histologic pattern is a well-described phenomenon. The converse phe nomenon, often called downgrading, is much less frequent. We report 2 patients in whom relapse with an indolent lymphoma was noted after che motherapy for higher-grade disease. Other previously reported cases ar e reviewed. The implications for appropriate management and pathogenes is are discussed.