NUCLEUS RAPHE OBSCURUS EVOKES 5-HT-1A RECEPTOR-MEDIATED MODULATION OFRESPIRATORY NEURONS

Authors
LALLEY PM BENACKA R BISCHOFF AM RICHTER DW
Citation
Pm. Lalley et al., NUCLEUS RAPHE OBSCURUS EVOKES 5-HT-1A RECEPTOR-MEDIATED MODULATION OFRESPIRATORY NEURONS, Brain research, 747(1), 1997, pp. 156-159
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
747
Issue
1
Year of publication
1997
Pages
156 - 159
Database
ISI
SICI code
0006-8993(1997)747:1<156:NROE5R>2.0.ZU;2-R
Abstract
We analysed in vivo the synaptic mechanisms underlying serotonin-media ted depression of expiratory neuronal discharges and phrenic nerve act ivity. We report that nucleus raphe obscurus stimulation not only abol ishes phrenic nerve activity, but also hyperpolarizes the membrane pot ential, depresses periodic synaptic drive potentials and thus action p otential discharges in caudal medullary expiratory neurons. These effe cts originate from pre- and post-synaptic inhibitory processes that in volve 5-HT-1A receptor activation.