MILD HEMOPHILIA-A FAILS TO PROTECT FROM CORONARY-ARTERY DISEASE - THEREPORT OF 2 CASES

The description of two additional cases of coronary artery disease in haemophiliacs is reported. Both patients are affected by mild haemophi lia A. The first one was not aware of his coagulation disorder and the refore he had never been treated with FVIII concentrates, despite the occurrence of severe and recurrent articular and gastric bleeding epis odes. He underwent cardiac catheterization that gave evidence of exten sive coronary atherosclerosis. Percutaneous transluminal coronary angi oplasty (PTCA) was then performed. The second patient had an inferior myocardial infarction. Influence of cardiovascular risk factors in hae mophiliacs and the possible role of thrombosis in the pathogenesis of atherosclerosis are discussed.