The cases are reported of 13 children seen over a 22 month period who
presented with a variety of acute neurological illnesses associated wi
th Mycoplasma pneumoniae infection. Although presentation with a decre
ased level of consciousness or seizures was common, psychosis, hemipar
esis, cranial nerve palsies, and Guillain-Barre syndrome were also see
n. In contrast with published reports, only one child had an associate
d chest infection. Although some children have been left with residual
disability, most have made a complete recovery. In this recent experi
ence, M pneumoniae is a not rare cause of neurological illness in chil
dhood and may present in unusual ways.