EFFECTIVENESS AND SAFETY OF MULTIDRUG INTRACAVERNOUS THERAPY FOR VASCULOGENIC IMPOTENCE

A four-drug vasoactive mixture (papaverine hydrochloride, prostaglandi n E1, phentolamine mesylate, atropine sulfate) was used for intracaver nous injection therapy in 94 patients with vasculogenic impotence as d iagnosed by color Doppler sonography and dynamic infusion cavernosomet ry-cavernosography. At a mean follow-up of twenty months, 66 patients (70%) are using the injections with the initial dose and are satisfied ; 14 patients (15%) are using the injections with a smaller dose than initially given; and 14 patients (15%) dropped intracavernous treatmen t. Only 4 patients (4%) were unable to achieve a sustained rigid erect ion during the mixture titration phase. Selected cases of vasculogenic impotence can be safely and effectively treated by the association of drugs which rely on different mechanisms of action, producing a pharm acologic synergism which enhances the overall therapeutic effect.