Primary involvement of the urethra by lymphoma is rare. We report the
first case of a primary urethral B-cell lymphoma as the initial manife
station of the acquired immune deficiency syndrome (AIDS). A fifty-sev
en-year-old black man was evaluated for obstructive voiding symptoms a
nd bloody urethral discharge. Workup revealed a urethral mass which, o
n pathologic examination, was a large B-cell lymphoma.