CYTOMEGALOVIRUS-INFECTION AFTER LIVER-TRANSPLANTATION IN CHILDREN

Post-liver transplant cytomegalovirus (CMV) infection (seroconversion or virus isolation) and CMV disease (infection plus clinical signs and symptoms) were studied in relation to pretransplant recipient and don or serology, age, nutritional status and the effect of paediatric vers us adult (reduced size) grafts. Of 70 children receiving 79 transplant s, 26 (37%) had evidence of CMV infection, and eight (11.5%) had evide nce of CMV disease, four of whom died. The primary infection rate (whe re the recipients were CMV negative) was 71% with mortality of 7% with most receiving a CMV-positive graft. The active secondary infection r ate (reactivation or reinfection, where the recipients were CMV positi ve) was 60% with mortality of 12.5%. No significant differences in inf ection or disease rates were found comparing malnourished versus well- nourished patients, or between those who received whole or reduced-siz e grafts. The high prevalence of CMV infections supports the view that clinical signs alone are inadequate to direct investigations for CMV. Both primary and active secondary CMV infection can result in serious morbidity and mortality in children receiving liver transplants. Thes e data do not support the strategy of providing immunoprophylaxis to s eronegative recipients only, at least in paediatric liver transplantat ion.