The occurrence of symptomatic congenital cytomegalovirus (CMV) infecti
on in two consecutive sisters is reported. The first sibling showed he
patosplenomegaly with slight hyperbilirubinaemia and abnormal liver fu
nction tests, right inguinal hernia, and peripheral lymphoedema. Her s
ister, the product of an uneventful pregnancy showing no signs of CMV
reactivation, had life threatening CMV disease, including microcephaly
, hepatitis with high serum bilirubin concentrations, and thrombocytop
enic purpura.