IMPROVED FLOW-INJECTION ANALYSIS (FIA) METHOD FOR DETERMINING SELENIUM IN BIOLOGICAL SAMPLES, AND THE EFFECT OF CAPTOPRIL ADMINISTRATION ONSELENIUM LEVELS AND GLUTATHIONE-PEROXIDASE ACTIVITY IN RAT

Authors
SUZUKI N FUJITA E YASUI H AOYAMA E TANAKA H NAKAGAWA T
Citation
N. Suzuki et al., IMPROVED FLOW-INJECTION ANALYSIS (FIA) METHOD FOR DETERMINING SELENIUM IN BIOLOGICAL SAMPLES, AND THE EFFECT OF CAPTOPRIL ADMINISTRATION ONSELENIUM LEVELS AND GLUTATHIONE-PEROXIDASE ACTIVITY IN RAT, Biological & pharmaceutical bulletin, 16(11), 1993, pp. 1069-1072
Citations number
33
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
16
Issue
11
Year of publication
1993
Pages
1069 - 1072
Database
ISI
SICI code
0918-6158(1993)16:11<1069:IFA(MF>2.0.ZU;2-2
Abstract
An improved flow injection analysis (FIA) method has been developed fo r the determination of trace selenium in biological samples, and this method has been applied to investigate the effect of captopril, an ant ihypertensive drug having a thiol group, on selenium concentrations in the rat blood, liver and urine. After oral administration of captopri l, selenium levels in the blood decreased, while those in the liver in creased significantly. However, no pronounced effect was observed on t he urinary excretion rate. The glutathione peroxidase activities in th e blood and the liver were comparable to the changes in the selenium l evels.