DISPOSITION OF ENANTIOMERS OF SULTOPRIDE IN A HUMAN, RATS AND RABBITS

Authors
KAMIZONO A INOTSUME N FUKUSHIMA S NAKANO M
Citation
A. Kamizono et al., DISPOSITION OF ENANTIOMERS OF SULTOPRIDE IN A HUMAN, RATS AND RABBITS, Biological & pharmaceutical bulletin, 16(11), 1993, pp. 1121-1123
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
16
Issue
11
Year of publication
1993
Pages
1121 - 1123
Database
ISI
SICI code
0918-6158(1993)16:11<1121:DOEOSI>2.0.ZU;2-G
Abstract
Pharmacokineties of sultopride enantiomers was examined following a si ngle dose in a human, rabbits and rats. Pharmacokinetic profiles were similar between (+)- and (-)-enantiomers of sultopride in human, where as the serum concentrations of (-)-sultopride were slightly higher tha n those of (+)-sultopride after i.v. administration of 50 mg/kg of rac emic sultopride to rats and rabbits.