ENHANCEMENT OF THE ANTITRICHOMONAL ACTIVITY OF 5-NITROIMIDAZOLE DERIVATIVES BY HYDROGEN-PEROXIDE

Authors
MATTANA A JULIANO C PICCI V FRANCONI F CAPPUCCINELLI P
Citation
A. Mattana et al., ENHANCEMENT OF THE ANTITRICHOMONAL ACTIVITY OF 5-NITROIMIDAZOLE DERIVATIVES BY HYDROGEN-PEROXIDE, The New microbiologica, 16(4), 1993, pp. 359-365
Citations number
NO
Categorie Soggetti
Microbiology
Journal title
The New microbiologica
ISSN journal
11217138 → ACNP
Volume
16
Issue
4
Year of publication
1993
Pages
359 - 365
Database
ISI
SICI code
1121-7138(1993)16:4<359:EOTAAO>2.0.ZU;2-0
Abstract
The in vitro sensitivity of nine Trichomonas vaginalis isolates to com monly employed 5-nitroimidazoles (metronidazole, nimorazole, ornidazol e and tinidazole) was evaluated in absence and in presence of sub-inhi bitory concentrations of hydrogen peroxide (H2O2). Co-incubation with H2O2 and 5-nitroimidazole compounds decreased the MIC values of the st rains exhibiting cross-resistance to these drugs. It was suggested tha t H2O2 produced in the inflammatory process during trichomonal infecti on could enhance the therapeutic effect of 5-nitroimidazole drugs.