ENDOGENOUS NITRIC-OXIDE COUNTERACTS ANTIGEN-INDUCED BRONCHOCONSTRICTION

Authors
PERSSON MG FRIBERG SG HEDQVIST P GUSTAFSSON LE
Citation
Mg. Persson et al., ENDOGENOUS NITRIC-OXIDE COUNTERACTS ANTIGEN-INDUCED BRONCHOCONSTRICTION, European journal of pharmacology, 249(3), 1993, pp. 180000007-180000008
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
249
Issue
3
Year of publication
1993
Pages
180000007 - 180000008
Database
ISI
SICI code
0014-2999(1993)249:3<180000007:ENCAB>2.0.ZU;2-N
Abstract
In anesthetized, artificially ventilated guinea pigs immunized against ovalbumin, challenge with aerosolized ovalbumin (0.1 mg) elicited a s ubstantial and sustained increase of insufflation pressure. The inhibi tor of endogenous nitric oxide (NO) synthesis, L-NAME (N-omega-nitro-L -arginine methylester, 30 mg kg(-l) i.v.), markedly augmented the resp onse, the potentiation of which could be prevented by NO (20 p.p.m.) i n the inhaled air. The results indicate an inhibitory effect of endoge nous NO on antigen-induced bronchoconstriction.