Mg. Persson et al., ENDOGENOUS NITRIC-OXIDE COUNTERACTS ANTIGEN-INDUCED BRONCHOCONSTRICTION, European journal of pharmacology, 249(3), 1993, pp. 180000007-180000008
In anesthetized, artificially ventilated guinea pigs immunized against
ovalbumin, challenge with aerosolized ovalbumin (0.1 mg) elicited a s
ubstantial and sustained increase of insufflation pressure. The inhibi
tor of endogenous nitric oxide (NO) synthesis, L-NAME (N-omega-nitro-L
-arginine methylester, 30 mg kg(-l) i.v.), markedly augmented the resp
onse, the potentiation of which could be prevented by NO (20 p.p.m.) i
n the inhaled air. The results indicate an inhibitory effect of endoge
nous NO on antigen-induced bronchoconstriction.