PROPERTIES OF THE MOUSE CONE-MEDIATED ELECTRORETINOGRAM DURING LIGHT ADAPTATION

Cone-mediated electroretinograms (ERGs) were obtained from normal mice during the course of light adaptation to a rod-desensitizing adapting field. Responses obtained during the early minutes of light adaptatio n were smaller in amplitude, and delayed in implicit time in compariso n to responses obtained to the same stimulus presented later during li ght adaptation, These changes resemble those observed in the human con e ERG obtained under similar stimulus conditions, and indicate that th e underlying mechanism may be similar. While the use of an adapting fi eld appears to isolate the mouse cone ERG, these adaptation-induced ch anges should be considered when evaluating this response.