A grade five through eight substance abuse prevention program, later i
ncorporated into the Michigan Model for Comprehensive School Health Ed
ucation, was developed, implemented, and evaluated. Results focus on s
tudents who received seven lessons on alcohol in grade six, and eight
lessons on tobacco, alcohol, marijuana, and cocaine in grade seven tau
ght by their regular classroom teachers (after a 6-hour training in th
e social pressures resistance skills curriculum). Students (N = 442) r
eceived either two years of the program or none, and completed individ
ually-coded questionnaires. Repeated measures analysis of variance res
ulted in significant treatment by occasion interactions on the use of
alcohol, cigarettes, marijuana, cocaine, and other drugs, as well as o
n knowledge. At the end of grade seven, program students' rates of sub
stance use had increased significantly less and knowledge of alcohol p
ressures, effects, and skills to resist had increased significantly mo
re than those of comparison students.