EFFECTS OF PARACETAMOL ON GLUTATHIONE-S-T RANSFERASE ACTIVITY IN MICE

Paracetamol (acetaminophen) 90 - 150 mg.kg-1 increased the activity of serum glutathione S-transferase (GST) and yet reduced the activities of liver microsomal and homogenate GST in mice. The GST activity was d ose- and time-related to paracetamol. A negative correlation was found between serum GST and liver homogenate GST, as well as between serum GST and liver microsomal GST. A good positive correlation between seru m GST and serum alanine aminotransferase (AAT) was also seen. In addit ion, butylated hydroxyanisole (BHA) and sodium ferulate (SF) remarkabl y reversed the changes of serum GST and serum AAT activities in parace tamol-treated mice. These results suggested that the conjugation level in liver was decreased in paracetamol-induced hepatotoxicity in mice.