CHAETOMELLA ACUTISETA PRODUCES CHAETOMELLIC ACIDS A AND B WHICH ARE REVERSIBLE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Authors
LINGHAM RB SILVERMAN KC BILLS GF CASCALES C SANCHEZ M JENKINS RG GARTNER SE MARTIN I DIEZ MT PELAEZ F MOCHALES S KONG YL BURG RW MEINZ MS HUANG L NALLINOMSTEAD M MOSSER SD SCHABER MD OMER CA POMPLIANO DL GIBBS JB SINGH SB
Citation
Rb. Lingham et al., CHAETOMELLA ACUTISETA PRODUCES CHAETOMELLIC ACIDS A AND B WHICH ARE REVERSIBLE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE, Applied microbiology and biotechnology, 40(2-3), 1993, pp. 370-374
Citations number
28
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Applied microbiology and biotechnology → ACNP
ISSN journal
01757598
Volume
40
Issue
2-3
Year of publication
1993
Pages
370 - 374
Database
ISI
SICI code
0175-7598(1993)40:2-3<370:CAPCAA>2.0.ZU;2-B
Abstract
Chaetomellic acids A and B, isolated from Chaetomella acutiseta, are s pecific inhibitors of farnesyl-protein transferase that do not inhibit geranylgeranyl transferase type 1 or squalene synthase. Chaetomellic acids A and B are reversible inhibitors, resemble farnesyl diphosphate and probably inhibit FPTase by substituting for farnesyl diphosphate. Chaetomellic acid production appears to be widespread within the genu s Chaetomella.