MACROPHAGE PROGENITORS FROM MOUSE BONE-MARROW AND SPLEEN DIFFER IN THEIR EXPRESSION OF THE LY-6C DIFFERENTIATION ANTIGEN

Authors
MCCORMACK JM LEENEN PJM WALKER WS
Citation
Jm. Mccormack et al., MACROPHAGE PROGENITORS FROM MOUSE BONE-MARROW AND SPLEEN DIFFER IN THEIR EXPRESSION OF THE LY-6C DIFFERENTIATION ANTIGEN, The Journal of immunology, 151(11), 1993, pp. 6389-6398
Citations number
43
Categorie Soggetti
Immunology
Journal title
The Journal of immunology
ISSN journal
00221767 → ACNP
Volume
151
Issue
11
Year of publication
1993
Pages
6389 - 6398
Database
ISI
SICI code
0022-1767(1993)151:11<6389:MPFMBA>2.0.ZU;2-5
Abstract
Using mAb and magnetic and fluorescence-activated cell sorting, togeth er with culturing in semisolid culture medium, we show that essentiall y all splenic macrophage progenitors are Ly-6C(hi)Mac-1-. By contrast, bone marrow macrophage progenitors were more heterogeneous in Ly-6C e xpression, the majority being restricted to the Ly-6C(dim)Mac-1- and t he Ly-6C-Mac-1- subsets. These findings provide immunophenotype eviden ce that macrophages in the spleen and bone marrow arise from different progenitors.