BESTATIN SPECIFICALLY ENHANCES THE NUMBER OF CD4-CELLS IN PERIPHERAL-BLOOD IN PATIENTS WHOSE CD8+ T-CELL NUMBERS ARE ALSO DEPRESSED( T)

Authors
MATHE G ITZHAKI M ORBACHARBOUYS S
Citation
G. Mathe et al., BESTATIN SPECIFICALLY ENHANCES THE NUMBER OF CD4-CELLS IN PERIPHERAL-BLOOD IN PATIENTS WHOSE CD8+ T-CELL NUMBERS ARE ALSO DEPRESSED( T), International journal of immunotherapy, 9(3), 1993, pp. 165-167
Citations number
8
Categorie Soggetti
Immunology
Journal title
International journal of immunotherapy → ACNP
ISSN journal
02559625
Volume
9
Issue
3
Year of publication
1993
Pages
165 - 167
Database
ISI
SICI code
0255-9625(1993)9:3<165:BSETNO>2.0.ZU;2-2
Abstract
A clinical trial was conducted on 34 patients whose absolute number of peripheral blood CD4+ T cells was below normal, and who were given be statin orally for a period of 3 weeks. Bestatin increased the absolute number of CD4+ T cells only in patients whose CD8+ T cells were also reduced. It would appear that normal numbers of CD8+ T cells controlle d attempts by the organism to alter the T4/T8 ratio.