Ns. Lipman et al., ESTRADIOL-17-BETA-SECRETING ADRENOCORTICAL TUMOR IN A FERRET, Journal of the American Veterinary Medical Association, 203(11), 1993, pp. 1552-1555
Sever generalized alopecia and marked vulvar enlargement were observed
in a 5-year-old spayed ferret with high serum estradiol concentration
s. A neoplastic left adrenal gland was removed. Staining of the neopla
stic cells for estradiol was demonstrated by use of immunohistochemist
ry. Clinical findings in this ferret were typical of adrenal-associate
d endocrinopathy, a syndrome characterized by increased secretion of a
drenocortical hormones by hyperplastic or neoplastic adrenal glands.