TOTAL SYNTHESIS OF AUREOBASIDIN-A, AN ANTIFUNGAL CYCLIC DEPSIPEPTIDE

Authors
KUROME T INAMI K INOUE T IKAI K TAKESAKO K KATO I SHIBA T
Citation
T. Kurome et al., TOTAL SYNTHESIS OF AUREOBASIDIN-A, AN ANTIFUNGAL CYCLIC DEPSIPEPTIDE, Chemistry Letters, (11), 1993, pp. 1873-1876
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
11
Year of publication
1993
Pages
1873 - 1876
Database
ISI
SICI code
0366-7022(1993):11<1873:TSOAAA>2.0.ZU;2-5
Abstract
A total synthesis of an antifungal cyclic depsipeptide aureobasidin A was first achieved mainly using PyBroP1) as a coupling reagent. The sy nthetic cyclized product was completely identical with the natural ant ibiotic in all respects. Some unexpected reactions due to N-methylamin o acid were also described.