EFFECT OF GAMMA-IRRADIATED CARBOHYDRATES ON ISOLATED SYNAPTIC-MEMBRANES

Authors
KALER GV LYSKOVA TI SHADYRO OI SAMOILENKO SG EDIMECHEVA IP AKSENTSEV SL KONEV SV
Citation
Gv. Kaler et al., EFFECT OF GAMMA-IRRADIATED CARBOHYDRATES ON ISOLATED SYNAPTIC-MEMBRANES, Radiation and environmental biophysics, 32(4), 1993, pp. 345-355
Citations number
39
Categorie Soggetti
Biophysics,"Radiology,Nuclear Medicine & Medical Imaging","Environmental Sciences
Journal title
Radiation and environmental biophysics → ACNP
ISSN journal
0301634X
Volume
32
Issue
4
Year of publication
1993
Pages
345 - 355
Database
ISI
SICI code
0301-634X(1993)32:4<345:EOGCOI>2.0.ZU;2-N
Abstract
The effect of gamma-irradiated solutions of carbohydrates, mainly gluc ose, upon Na+, K+-ATPase and lipid peroxidation in rat brain synaptoso mal membranes was studied. The membrane damage by irradiated glucose w as enhanced in the presence of Fe2+ and was diminished when a free-rad ical scavenger (BHT) or metal chelators (EDTA, EGTA) were present. It is suggested that a key element in the free-radical membrane damage by irradiated carbohydrates is an Fe2+-complex of some species of the ra diolysis products. Participation of radiotoxins of carbohydrate origin in radiobiological effects is discussed.