TETRACAINE PROTECTS AGAINST COCAINE LETHALITY IN MICE

Citation
Sad. Grant et al., TETRACAINE PROTECTS AGAINST COCAINE LETHALITY IN MICE, Annals of emergency medicine, 22(12), 1993, pp. 1799-1803
Citations number
NO
Categorie Soggetti
Emergency Medicine & Critical Care
ISSN journal
01960644
Volume
22
Issue
12
Year of publication
1993
Pages
1799 - 1803
Database
ISI
SICI code
0196-0644(1993)22:12<1799:TPACLI>2.0.ZU;2-C
Abstract
Study hypothesis: Tetracaine will enhance cocaine toxicity. Study popu lation: Two hundred forty female Swiss albino mice weighing 27 to 45 g . Methods: Intraperitoneal injections of tetracaine and cocaine were g iven to groups of ten mice each in a controlled, blinded fashion. Eith er tetracaine or an equal volume of normal saline was given five minut es before one of six incremental doses of cocaine, ranging from 60 to 110 mg/kg. The experiment was repeated twice using two different doses of tetracaine: either an LD10 (40 mg/kg determined from preliminary s tudies), or one-twentieth of the dose of cocaine (which approximates t he ratio used in tetracaine, epinephrine, and cocaine). Lethality was recorded at 24 hours. Lethality between groups was compared with a Wil coxon sign-rank test. Results: Tetracaine reduced cocaine lethality at all doses. This reduction in lethality was statistically significant at both tetracaine doses (P<.05). Conclusion: In the mouse, pretreatme nt with tetracaine significantly decreases cocaine lethality.