SYNTHESIS OF OPTICALLY-ACTIVE ALPHA-(IMIDAZOL-1-YL, PURIN-9-YL OR URACIL-1-YL) PROPANOIC AND SUCCINIC ACID-DERIVATIVES

Authors
BIRKETT PR KING H CHAPLEO CB EWING DF MACKENZIE G
Citation
Pr. Birkett et al., SYNTHESIS OF OPTICALLY-ACTIVE ALPHA-(IMIDAZOL-1-YL, PURIN-9-YL OR URACIL-1-YL) PROPANOIC AND SUCCINIC ACID-DERIVATIVES, Tetrahedron, 49(47), 1993, pp. 11029-11036
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
49
Issue
47
Year of publication
1993
Pages
11029 - 11036
Database
ISI
SICI code
0040-4020(1993)49:47<11029:SOOAPO>2.0.ZU;2-I
Abstract
An efficient route is reported to chiral propanoic and succinic acid d erivatives substituted in the alpha-position with adenine, hypoxanthin e and uracil groups. These nucleic acid base derivatives are obtained in optically pure form by a procedure which starts from an amino acid as a convenient chiral synthon.