We compared the predictive values of three measurements of sensory con
duction of the median nerve at the carpal tunnel (maximum latency diff
erence [MLD], 8-cm latency [S8], and 14-cm latency [S14]) in 2334 hand
s of industrial workers, workers' compensation patients, and students.
The MLD was determined by the centimetric technique. The MLD was the
most sensitive and efficient measurement for predicting carpal tunnel
syndrome (CTS). An MLD greater-than-or-equal-to 0.40 ms correctly iden
tified 86.3% of 753 hands with CTS. The MLD correlated best with CTS a
nd with the primary diagnostic category (CAT). MLD was the second fact
or selected in stepwise regression analysis for CAT (numbness was firs
t and S8 was third). The MLD was the most important factor for predict
ing persistent or de novo CTS in a 5-year follow-up of 630 hands. Thus
, the MLD was the most reliable nerve conduction study measurement for
predicting current or future CTS in these subjects' hands. (C) 1993 J
ohn Wiley & Sons, Inc.