SERUM GAMMA-GLUTAMYL-TRANSPEPTIDASE AS A DIFFERENTIAL DIAGNOSTIC-AID IN JAUNDICE IN CANINES - (A CLINICOPATHOLOGICAL STUDY)

In hepatic damage, many proteins are released into the blood. of which several are enzymes and measurement of their activity has proved to h ave a diagnostic value. The presence of Gamma-Glutamyl Transpeptidase (GGT) in the human serum in association with liver disease was demonst rated as early as 1960. GGT was found to be elevated in dogs subjected to ligation of common bile duct (Shell and Hornbuckle, 1979 ; Bolbol, 1981 ; Denovo and Prasse, 1983). GGT levels in serum were indicative of cholestatic disorders of dog (Braun et 41., 1983). Since GGT is not widely used as a biochemical test in clinical cases of jaundice, in v eterinary practice, a study was undertaken to compare the significance of serum GGT in different types of jaundice in dogs.