G. Splitter et Sh. Choi, BOVINE NATURAL-KILLER ACTIVITY AGAINST VIRALLY INFECTED-CELLS INHIBITED BY MONOCLONAL-ANTIBODIES, Veterinary immunology and immunopathology, 39(1-3), 1993, pp. 269-274
Forty-four monoclonal antibodies (mAbs) were evaluated for their abili
ty to alter natural killer (NK) cell lysis of virally infected target
cells. Six of the mAbs inhibited the lysis of the target cells, while
one of the mAbs enhanced lysis. Four of the inhibitory mAbs, CACT26A,
CACT16A, CACTB45A and MUC76A, had very marked activity. These mAbs wit
h inhibitory or enhancing activity recognized (1) WC2 molecules (CACTB
44A, CACT16A, CACT26A) present on putative NK cells, (2) molecules on
granulocytes, monocytes, a subpopulation of lymphocytes (CACTB45A and
TH2A), (3) CD11a (MUC76A), and a protein of CD3 (MM1A).