BOVINE NATURAL-KILLER ACTIVITY AGAINST VIRALLY INFECTED-CELLS INHIBITED BY MONOCLONAL-ANTIBODIES

Authors
SPLITTER G CHOI SH
Citation
G. Splitter et Sh. Choi, BOVINE NATURAL-KILLER ACTIVITY AGAINST VIRALLY INFECTED-CELLS INHIBITED BY MONOCLONAL-ANTIBODIES, Veterinary immunology and immunopathology, 39(1-3), 1993, pp. 269-274
Citations number
9
Categorie Soggetti
Immunology,"Veterinary Sciences
Journal title
Veterinary immunology and immunopathology → ACNP
ISSN journal
01652427
Volume
39
Issue
1-3
Year of publication
1993
Pages
269 - 274
Database
ISI
SICI code
0165-2427(1993)39:1-3<269:BNAAVI>2.0.ZU;2-F
Abstract
Forty-four monoclonal antibodies (mAbs) were evaluated for their abili ty to alter natural killer (NK) cell lysis of virally infected target cells. Six of the mAbs inhibited the lysis of the target cells, while one of the mAbs enhanced lysis. Four of the inhibitory mAbs, CACT26A, CACT16A, CACTB45A and MUC76A, had very marked activity. These mAbs wit h inhibitory or enhancing activity recognized (1) WC2 molecules (CACTB 44A, CACT16A, CACT26A) present on putative NK cells, (2) molecules on granulocytes, monocytes, a subpopulation of lymphocytes (CACTB45A and TH2A), (3) CD11a (MUC76A), and a protein of CD3 (MM1A).