TESTING METHOD FOR MECHANICAL-PROPERTIES OF FIBRIN GLUE

A testing method was developed to evaluate the mechanical properties o f a fibrin adhesive in an effort to correlate mechanical strength to f ibrinogen content. Autologous fibrin adhesives with varying fibrinogen content were loaded to failure in shear using a mechanical testing ma chine. The method developed was capable of distinguishing a mechanical strength difference among the three fibrin sample lots used in the st udy. A number of parameters were evident that could lead to testing va riability. The development of a more sophisticated component delivery system would greatly reduce the variability of these parameters and th us, the product reliability. Ultimately, the information gathered from the current and future studies will form a type of quality control st andard to directly correlate the percentage of fibrinogen in a particu lar sample to its adhesive performance. (C) 1993 John Wiley & Sons, In c.