Xh. Cheng et al., PREPARATION OF HYDROPHILIC BENZHYDRYLAMIN E RESIN AND ITS APPLICATIONIN SOLID-PHASE PEPTIDE-SYNTHESIS, Huaxue xuebao, 51(10), 1993, pp. 1005-1009
Polyacrylamide resin containing easter groups was prepared with revers
e phase suspension copolymerization, onto which the benzhydrylamine gr
oups was introduced by ethylene diamine substitution and two steps of
condensation reactions. The influence of reaction conditions was studi
ed. With the use of the prepared support, a model peptide was synthesi
zed. Condensation yields in the peptide synthesis were measured. The y
ields and purity of the peptide were satisfactory.