MYOGLOBIN ELIMINATION IN END-STAGE KIDNEY-DISEASE PATIENTS ON RENAL REPLACEMENT TREATMENT

Increased serum myoglobin levels were previously found in patients wit h chronic renal failure. In this report we have studied the effects of dialysis on myoglobin elimination in patients on CAPD, IPD, cuprophan and polyacrylonitrile (PAN) membrane hemodialysis. Peritoneal dialysi s removed a significant amount of myoglobin, CAPD 480 +/- 65 mu g/day, IPD 270 +/- 25 mu g/12 h treatment, while with cuprophan dialysis non e, and with PAN dialysis only an insignificant amount of myoglobin. Th e serum myoglobin levels were 250 +/- 18 and 264 +/- 14 mu g/l on cupr ophan and a 3 month dialysis on PAN membrane, respectively. Markedly i ncreased serum levels were also found in CAPD and IPD patients on peri toneal dialysis, 227 +/- 25 and 286 +/- 32 mu g/l respectively. This s tudy has shown that there is an increased serum myoglobin concentratio n in end-stage kidney disease patients on dialysis. Although peritonea l membrane is permeable to myoglobin, a relatively small amount is rem oved, and the serum level in CAPD and IPD patients was not significant ly different from the serum myoglobin concentration in hemodialysis pa tients. Furthermore myoglobin could not be removed by hemodialysis mem brane and an analysis of ifs important extrarenal catabolism level poi nts were analyzed.